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23.10.2013

RESEARCH HIGHLIGHTS

VKTK haluaa osaltaan tuoda esiin kliinisen tutkimuksen edistysaskeleita yhteistyökumppaninsa Suomalainen Lääkäriseura Duodecimin kliinisen tutkimuksen teemavuosien kunniaksi.

Julkaisemme uutisissamme RESEARCH HIGHLIGHTS otsikon alla linkkejä valikoituihin VKTK:n piirissä tehtyihin merkittäviin kliinisen lääketieteen julkaisuihin.

 

Uusin Research Highlight artikkeli

Circulating Concentrations of Soluble Receptor for AGE Are Associated With Age and AGER Gene Polymorphisms in Children With Newly Diagnosed Type 1 Diabetes. Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Laine AP, Groop PH, Knip M. Diabetes Care. 2014


OBJECTIVE
We analyzed the relationship among soluble receptor for advanced glycation end products (sRAGEs), the clinical phenotype, HLA genotype, and risk-associated single nucleotide polymorphisms (SNPs) in the AGER gene in a large population of Finnish children with newly diagnosed type 1 diabetes.RESEARCH DESIGN AND METHODSSamples from 2,115 clinically phenotyped children <15 years of age in whom type 1 diabetes was diagnosed and 316 control subjects were analyzed for sRAGEs. Three SNPs of AGER, previously associated with HLA-DR/DQ haplotype independent diabetes risk (rs2070600, rs9469089, and rs17493811), were analyzed in 1,390 affected subjects.

RESULTS
Children with type 1 diabetes and control subjects had similar sRAGE concentrations (1,171 vs. 1,153 pg/mL, P = 0.48). There was a correlation between age at diagnosis and serum sRAGE concentrations (r = 0.10, P < 0.001) among the patients but not among the control subjects. Children <2 years of age had the lowest concentrations in the diabetic population (1,027 vs. 1,181 pg/mL, P < 0.001), and the highest among the control subjects (1,329 vs. 1,140 pg/mL, P = 0.04). Ketoacidosis at diagnosis was associated with reduced concentrations (1,086 vs. 1,190 pg/mL, P < 0.001). HLA DR3/DR4 heterozygosity and the DR3 allele were associated with reduced sRAGE concentrations. The predisposing AA genotype of rs2070600 was associated with decreased sRAGE concentrations, while the protective CC genotype of rs9469089 was linked to increased concentrations.

CONCLUSIONS
Age and AGER polymorphisms are associated with the circulating sRAGE concentration among children with type 1 diabetes. The observations of reduced sRAGE concentrations in young children, in those with ketoacidosis, and in carriers of the high-risk HLA DR3/DR4 genotype suggest that decreased sRAGE concentration reflects a more aggressive disease phenotype.

 

Aiemmat Research Highlight artikkelit

Postnatal ovarian activation has effects in estrogen target tissues in infant girls. Kuiri-Hänninen T, Haanpää M, Turpeinen U, Hämäläinen E, Seuri R, Tyrväinen E, Sankilampi U, Dunkel L. J Clin Endocrinol Metab. 2013, 98(12):4709-4716.


In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders. Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A.Int J Cancer. 2013


Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. Puurunen J, Piltonen T, Puukka K, Ruokonen A, Savolainen MJ, Bloigu R, Morin-Papunen L, Tapanainen JS. J Clin Endocrinol Metab. 2013, 98(12):4798-4807

 

In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548. Kähkönen E*, Jambor I*, Kemppainen J, Lehtiö K, Grönroos TJ, Kuisma A, Luoto P, Sipilä HJ, Tolvanen T, Alanen K, Silén J, Kallajoki M, Roivainen A, Schäfer N, Schibli R, Dragic M, Johayem A, Valencia R, Borkowski S, Minn H.*equal contribution. Clin Cancer Res. 2013 19(19):5434-43.

 

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients. Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, Borra R, Parkkola R, Mari A, Lehtimäki T, Pham T, Laine J, Kärjä V, Pihlajamäki J, Nelimarkka L, Nuutila P. J Hepatol. 2013.

 

Use of electronic health records for automated screening of growth disorders in primary care. Sankilampi U, Saari A, Laine T, Miettinen PJ, Dunkel L., JAMA. 2013, 310(10):1071-1072.

 

Serum FGF21 Increases With Hepatic Fat Accumulation in Pediatric Onset Intestinal Failure. Mutanen A, Heikkilä P, Lohi J, Raivio T, Jalanko H, Pakarinen MP. J Hepatol. 2013


Cardiovascular morbidity in long-term survivors of early-onset cancer: A population-based study. Kero AE, Järvelä LS, Arola M, Malila N, Madanat-Harjuoja LM, Matomäki J, Lähteenmäki PM. Int J Cancer. 2013


Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Rajala HL, Eldfors S, Kuusanmäki H, van Adrichem AJ, Olson T, Lagström S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S. Blood. 121(22):4541-50, 2013.

Cardiac MRI in the evaluation of the late effects of anthracyclines among long-term survivors of childhood cancer. Ylänen K, Poutanen T, Savikurki-Heikkilä P, Rinta-Kiikka I, Eerola A, Vettenranta K. J Am Coll Cardiol. 61(14):1539-47, 2013.

 

Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure. Mutanen A, Lohi J, Heikkilä P, Koivusalo AI, Rintala RJ, Pakarinen MP. Hepatology. 2013.


Kalliola S et al. Maternal smoking affects lung function and airway inflammation in young children with multiple-trigger wheeze. J Allergy Clin Immunol, 2013; 131:730-735.

Anna Parkkola et al, Extended Family History of Type 1 Diabetes and Phenotype and Genotype of Newly Diagnosed Children. Diabetes Care. 2013; 36:348-354

 

Hanna Koskela et al, Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia, NEJM 2012; 366:1905-1913


Tähtinen PA, Laine MK, Huovinen P, Jalava J, Ph.D., Ruuskanen O, and Ruohola A. A Placebo-Controlled Trial of Antimicrobial Treatment for Acute Otitis Media. NEJM 2011; 364:116-126

 

Jaakkola S, Lyytinen HK, Dyba T, Ylikorkala O, Pukkala E. Endometrial cancer associated with various forms of postmenopausal hormone therapy: A case control study. Int. J. Cancer 2011; 128: 1644-51

 

Mehdi Farshchian, Atte Kivisaari, Risto Ala-aho, Pilvi Riihilä, Markku Kallajoki, Reidar Grénman, Juha Peltonen, Taina Pihlajaniemi, Ritva Heljasvaara, Veli-Matti Kähäri. Serpin Peptidase Inhibitor Clade A Member 1 (SerpinA1): a Novel Biomarker for Progression of Cutaneous Squamous Cell Carcinoma. Am J Pathol 2011 Sept; 179(3):1110-19

 

Anniina Färkkilä et al. Serum vascular endothelial growth factor A (VEGF) is elevated in patients with ovarian granulosa cell tumor (GCT), and VEGF inhibition by bevacizumab induces apoptosis in GCT in vitro.J Clin Endocrinol Metab. 2011 Dec;96(12):E1973-81.

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