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7.1.2015

RESEARCH HIGHLIGHTS

VKTK haluaa osaltaan tuoda esiin kliinisen tutkimuksen edistysaskeleita yhteistyökumppaninsa Suomalainen Lääkäriseura Duodecimin kliinisen tutkimuksen teemavuosien kunniaksi.

Julkaisemme uutisissamme RESEARCH HIGHLIGHTS otsikon alla linkkejä valikoituihin VKTK:n piirissä tehtyihin merkittäviin kliinisen lääketieteen julkaisuihin.

 

Uusin Research Highlight artikkeli

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma. Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Toriseva M, Kivisaari A, Ala-Aho R, Kallajoki M, Veräjänkorva E, Honkanen HK, Heljasvaara R, Pihlajaniemi T, Grénman R, Peltonen J, Peltonen S, Kähäri VM. J Invest Dermatol. 2015.

Keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. We have examined the role of Eph/ephrin signaling in the progression of cSCC. Analysis of the expression of EPH and EFN families in cSCC cells and normal epidermal keratinocytes revealed overexpression of EPHB2 mRNA in cSCC cells and cSCC tumors in vivo. Tumor cell-specific overexpression of EphB2 was detected in human cSCCs and in chemically-induced mouse cSCCs with immunohistochemistry, whereas the expression of EphB2 was low in premalignant lesions and normal skin. Knockdown of EphB2 expression in cSCC cells suppressed growth and vascularization of cSCC xenografts in vivo and inhibited proliferation, migration, and invasion of cSCC cells in culture. EphB2 knockdown down-regulated expression of genes associated with biofunctions cell viability, migration of tumor cells and invasion of tumor cells. Among the genes most down-regulated by EphB2 knockdown were MMP1 and MMP13. Moreover, activation of EphB2 signaling by ephrin-B2-Fc enhanced production of invasion proteinases MMP13 and MMP1, and invasion of cSCC cells. These findings provide mechanistic evidence for the role of EphB2 in the early progression of cSCC to the invasive stage and identify EphB2 as a putative therapeutic target in this invasive skin cancer.

 

Aiemmat Research Highlight artikkelit

Obesity Is Associated with Decreased μ-Opioid But Unaltered Dopamine D2 Receptor Availability in the Brain. Karlsson HK, Tuominen L, Tuulari JJ, Hirvonen J, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L. J Neurosci. 2015 35(9):3959-65.

Systematic growth monitoring for the early detection of celiac disease in children. Saari A, Harju S, Mäkitie O, Saha MT, Dunkel L, Sankilampi U. JAMA Pediatr. 2015 169(3):e1525.

Immunological data from cancer patients treated with Ad5/3 E2F Δ24 GMCSF suggests utility for tumor immunotherapy. Hemminki O, Parviainen S, Juhila J, Turkki R, Linder N, Lundin J, Kankainen M, Ristimäki A, Koski A, Liikanen I, Oksanen M, Nettelbeck DM, Kairemo K, Partanen K, Joensuu T, Kanerva A, Hemminki A. Oncotarget. 2015

Complement Factor I Promotes Progression of Cutaneous Squamous Cell Carcinoma. Riihilä P, Nissinen L, Farshchian M, Kivisaari A, Ala-Aho R, Kallajoki M, Grénman R, Meri S, Peltonen S, Peltonen J, Kähäri VM. J Invest Dermatol. 2014

Central executive network in young people with familial risk for psychosis - The Oulu Brain and Mind Study. Jukuri T, Kiviniemi V, Nikkinen J, Miettunen J, Mäki P, Mukkala S, Koivukangas J, Nordström T, Parkkisenniemi J, Moilanen I, Barnett JH, Jones PB, Murray GK, Veijola J. Schizophr Res. 2014

Clinical profile and influences on outcomes in patients hospitalized for acute pericarditis. Kytö V, Sipilä J, Rautava P. Circulation. 2014;130(18):1601-6.

Microsatellite polymorphism in the heme oxygenase-1 promoter is associated with nonsevere and late-onset preeclampsia. Kaartokallio T, Klemetti MM, Timonen A, Uotila J, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H. Hypertension. 2014;64(1):172-7

Circulating Concentrations of Soluble Receptor for AGE Are Associated With Age and AGER Gene Polymorphisms in Children With Newly Diagnosed Type 1 Diabetes. Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Laine AP, Groop PH, Knip M. Diabetes Care. 2014, 37:1975-81

Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma. Riihilä PM, Nissinen LM, Ala-aho R, Kallajoki M, Grénman R, Meri S, Peltonen S, Peltonen J, Kähäri VM. J Invest Dermatol. 2014;134(2):498-506

Postnatal ovarian activation has effects in estrogen target tissues in infant girls. Kuiri-Hänninen T, Haanpää M, Turpeinen U, Hämäläinen E, Seuri R, Tyrväinen E, Sankilampi U, Dunkel L. J Clin Endocrinol Metab. 2013, 98(12):4709-4716

In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders. Hemminki O, Immonen R, Närväinen J, Kipar A, Paasonen J, Jokivarsi KT, Yli-Ollila H, Soininen P, Partanen K, Joensuu T, Parvianen S, Pesonen SK, Koski A, Vähä-Koskela M, Cerullo V, Pesonen S, Gröhn OH, Hemminki A. Int J Cancer. 2013;134, 2878-90

Statin Therapy Worsens Insulin Sensitivity in Women With Polycystic Ovary Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. Puurunen J, Piltonen T, Puukka K, Ruokonen A, Savolainen MJ, Bloigu R, Morin-Papunen L, Tapanainen JS. J Clin Endocrinol Metab. 2013, 98(12):4798-4807

In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548. Kähkönen E*, Jambor I*, Kemppainen J, Lehtiö K, Grönroos TJ, Kuisma A, Luoto P, Sipilä HJ, Tolvanen T, Alanen K, Silén J, Kallajoki M, Roivainen A, Schäfer N, Schibli R, Dragic M, Johayem A, Valencia R, Borkowski S, Minn H.*equal contribution. Clin Cancer Res. 2013 19(19):5434-43.

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients. Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, Borra R, Parkkola R, Mari A, Lehtimäki T, Pham T, Laine J, Kärjä V, Pihlajamäki J, Nelimarkka L, Nuutila P. J Hepatol. 2013;60(2):377-383

Use of electronic health records for automated screening of growth disorders in primary care. Sankilampi U, Saari A, Laine T, Miettinen PJ, Dunkel L., JAMA. 2013, 310(10):1071-1072.

Serum FGF21 Increases With Hepatic Fat Accumulation in Pediatric Onset Intestinal Failure. Mutanen A, Heikkilä P, Lohi J, Raivio T, Jalanko H, Pakarinen MP. J Hepatol. 2014; 60(1), 183-190

Cardiovascular morbidity in long-term survivors of early-onset cancer: A population-based study. Kero AE, Järvelä LS, Arola M, Malila N, Madanat-Harjuoja LM, Matomäki J, Lähteenmäki PM. Int J Cancer. 2014 (134) 664-673

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Rajala HL, Eldfors S, Kuusanmäki H, van Adrichem AJ, Olson T, Lagström S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S. Blood. 121(22):4541-50, 2013.

Cardiac MRI in the evaluation of the late effects of anthracyclines among long-term survivors of childhood cancer. Ylänen K, Poutanen T, Savikurki-Heikkilä P, Rinta-Kiikka I, Eerola A, Vettenranta K. J Am Coll Cardiol. 61(14):1539-47, 2013.

Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure. Mutanen A, Lohi J, Heikkilä P, Koivusalo AI, Rintala RJ, Pakarinen MP. Hepatology. 2013; 50 (2), 729-738

Kalliola S et al. Maternal smoking affects lung function and airway inflammation in young children with multiple-trigger wheeze. J Allergy Clin Immunol, 2013; 131:730-735.

Anna Parkkola et al, Extended Family History of Type 1 Diabetes and Phenotype and Genotype of Newly Diagnosed Children. Diabetes Care. 2013; 36:348-354

Hanna Koskela et al, Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia, NEJM 2012; 366:1905-1913

Tähtinen PA, Laine MK, Huovinen P, Jalava J, Ph.D., Ruuskanen O, and Ruohola A. A Placebo-Controlled Trial of Antimicrobial Treatment for Acute Otitis Media. NEJM 2011; 364:116-126

Jaakkola S, Lyytinen HK, Dyba T, Ylikorkala O, Pukkala E. Endometrial cancer associated with various forms of postmenopausal hormone therapy: A case control study. Int. J. Cancer 2011; 128: 1644-51

Mehdi Farshchian, Atte Kivisaari, Risto Ala-aho, Pilvi Riihilä, Markku Kallajoki, Reidar Grénman, Juha Peltonen, Taina Pihlajaniemi, Ritva Heljasvaara, Veli-Matti Kähäri. Serpin Peptidase Inhibitor Clade A Member 1 (SerpinA1): a Novel Biomarker for Progression of Cutaneous Squamous Cell Carcinoma. Am J Pathol 2011 Sept; 179(3):1110-19.

Anniina Färkkilä et al. Serum vascular endothelial growth factor A (VEGF) is elevated in patients with ovarian granulosa cell tumor (GCT), and VEGF inhibition by bevacizumab induces apoptosis in GCT in vitro.J Clin Endocrinol Metab. 2011 Dec;96(12):E1973-81.

VKTK

Biomedicum Helsinki
Haartmaninkatu 8
PL 700, 00029 HUS
Puhelin: +358 50 4154708
e-mail: vktk(at)helsinki.fi

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